Abstract:Objective To study the expression and clinical significance of signal molecule Nrf2 in pulmonary adenocarcinoma tissues. Methods 88 tissue samples of pulmonary adenocarcinoma and 20 normal lung tissues were collected as research subject. The expressions of Nrf2 in lung tissues were identified by immune histochemistry. Results The positive expression rate of Nrf2 was less than 10 % in normal lung tissue, while it was 69.3 % in tissue samples of pulmonary adenocarcinoma, and 73.3 % in samples combined with metastasis of lymph nodes. The positive expression rate of Nrf2 was higher in poorly differentiated group (84.6 %) than that in middle (76.4 %) and high differentiation group (70.7 %). Conclusion The expression of Nrf2 was upregulated in tissues of pulmonary adnocarcinoma, and it was related with the degree of differentiation and lymph node metastasis of lung adenocarcinoma.