Objective To study the efficacy of KTP laser combined annular silicone tube implantation for treatment of lacrimal duct obstruction and the complications. Methods Totally 142 cases with lacrimal duct obstruction in our hospial from March 2012 to March 2015 were chosen as research subjects. Depending on the different treatment methods, they were randomly divided into observation group and control group. The patients in the observation group were given KTP laser combined with annular silicone tube implantion, while those iin the control group only received KTP laser treatment. The therapeutic effect, postoperative complications and recurrence rate were compared between the two groups. Results The total effective rate 6 months after surgery was 92.13% in the observation group which was significantly higher than 81.18% in the control group (P < 0.05). The satisfaction score in the observation group was significantly higher than that in the control group (P < 0.05). The incidence of complications and recurrence rate in the observation group were significantly lower than those in the control group (P < 0.05). Conclusions For treatment of lacrimal duct obstruction, KTP laser combined with annular silicone tube implantation can improve the efficacy and reduce complications and recurrence rate. It is a very worthwhile treatment program in clinic.