Objective To summarize the experience of surgery of total anomalous pulmonary venous connection (TAPVC) in infants, and analyze the risk factors. Methods A total of 102 consecutive neonates undergoing surgical correction of total anomalous pulmonary venous connection in the Third Affiliated Hospital of Zhengzhou University between June 2008 and June 2016 were selected. There were 57 males and 45 females with the mean weight of 5.5 kg at the mean age of 3 m. Clinical variables possibly associated with death were examined using logistic regression analysis. Results There were 9 operative deaths (8.8%), including 5 patients of supracardiac type, 2 patients of intracardiac type, and 2 patients of infracardiac type; 6 died of low cardiac output, and 3 died of pneumonia. Logistic regression analysis showed that preoperative pulmonary infection, anatomic classification, aortic clamping time, time of cardiovascular bypass and weight were the risk factors for postoperative mortality. Conclusions TAPVC operation for infants can obtain satisfactory results. Preoperative pulmonary infection, anatomic classification, aortic clamping time, cardiopulmonary bypass time and weight are the risk factors for operation.