Objective To analyze the effect of Propofol and Sevoflurane intravenous-inhalation compound anesthesia on post-operative recovery quality of patients with liver cirrhosis. Methods Seventy-two patients diagnosed as liver cirrhosis who underwent partial hepatic resection in Baodi Clinical College of Tianjin Medical University between 2015 and 2017 were chosen and randomly divided into two groups. Each group had 36 cases. The patients of the control group accepted total Propofol anesthesia by intravenous infusion, and the patients of the observation group were given Propofol and Sevoflurane intravenous-inhalation compound anesthesia. The modified OAA/S score and the modified Aldrete score were recorded and compared between the two groups immediately after extubation (T0), and 10 (T1), 30 (T2) and 60 min (T3) after extubation. The post-operative indexes of recovery time, spontaneous respiration recovery time, extubation time, bispectral index (BIS) and agitation occurrence were compared between the two groups. The incidences of post-operative complications such as cough response and nausea and vomiting were compared between the two groups. Results The modified OAA/S score and the modified Aldrete score were different at different time points (P < 0.05). The modified OAA/S score and the modified Aldrete score were different between the two groups (P < 0.05). Compared to the control group, the modified OAA/S score and the modified Aldrete score were higher in the observation group (P < 0.05). The variation trends of the modified OAA/S score and the modified Aldrete score in the two groups were different (P < 0.05). The recovery time, spontaneous respiration recovery time and extubation time in the observation group were shorter, the BIS and agitation occurrence in the observation group were lower than those in the control group (P < 0.05). The incidences of anesthesia-related complications were not significantly different between the two groups (P > 0.05). Conclusions The intravenous-inhalation compound anesthesia with Propofol and Sevoflurane can improve the recovery quality and the safety is perfect.