Objective To explore the effect of weight management on the glucose and lipid metabolisms in the obese patients with polycystic ovary syndrome (PCOS). Methods A total of 70 obese women with PCOS were divided into two groups with the control group administered by Metformin and the intervention group managed with weight management in addition to Metformin. The glucose and lipid metabolism indicators were measured and compared on day 0, 15, 30 and 45. Results The levels of TG, TC, FPG, 2hPPG, FINS and PINS after intervention had significant differences at different time points (P < 0.05). The levels of TG, TC, 2hPPG, FINS and PINS after intervention had significant differences between the 2 groups (P < 0.05). The variation trends of TG, TC, 2hPPG and PINS had significant differences between the 2 groups (P < 0.05). Conclusions The weight management on the basis of drug therapy for the obese patients with PCOS can significantly improve the metabolic disorders and enhance the effect of drug therapy.