Objective To investigate the effect of laser cavity coagulation under femoral nerve block anesthesia and tumescent anesthesia for varicose veins of lower limbs. Methods Sixty cases of varicose veins in Suzhou Hospital Affiliated to Nanjing Medical University were randomly divided into two groups, i.e. a group of laser cavity coagulation treatment under femoral nerve block anesthesia and swelling anesthesia (group A), and a group of high ligation treatment under traditional lumbar anesthesia (group B). The pain score, operation time, hospitalization time and clinical therapeutic effect of the two groups were compared. Results There was no significant difference in the pain score between the two groups (P > 0.05). The operation time and hospitalization time in the group A were significantly shorter that those in the group B (P < 0.05). The total effective rate after treatment in the group A (96.7%) was significantly higher than that of the group B (80.0%). Conclusions The treatment of varicose great saphenous veins of lower extremities by laser cavity coagulation under femoral nerve block anesthesia and tumescent anesthesia has the advantages of clear curative effect, high safety, few complications and shorter hospitalization time, hence it is of high clinical value.