Objective To investigate the effect of Atorvastatin combined with Yiqi Yangyin prescription on diabetic nephropathy (DN) and on the levels of inflammatory factors, hemorheology and renal function. Methods Ninety cases of DN patients who were treated in Department of Nephropathy in Integrated Traditional Chinese and Western Medicine Hospital of Southern Medical University from October 2016 to December 2017 were selected. According to the random digital table method, the patients were divided into a small-dose group, a medium-dose group and a large-dose group, with 30 cases in each group. All patients were treated with Metformin Hydrochloride Tablets and Yiqi Yangyin prescription, on this basis, the small-dose group, mediumdose group and large-dose group were treated with Atorvastatin 10, 20 and 40 mg/d respectively. The inflammatory factors, hemorheology, renal function, clinical efficacy and adverse reactions were compared among the three groups. Results After 1 month of treatment, the levels of hypersensitive C-reaction protein, tumor necrosis factor-α and interleukin-6 in the large-dose group were lower than those in the medium-dose group and the small-dose group (P < 0.05). The whole blood viscosity (low shear, middle shear and high shear) and plasma viscosity in the large-dose group were lower than those in medium-dose group and the small-dose group (P < 0.05). Urinary albumin excretion rate, blood urea nitrogen and serum creatinine levels in the large-dose group were lower than those in the medium-dose group and the small-dose group (P < 0.05). There was no significant difference in the total effective rate or adverse reaction among the three groups (P > 0.05). Conclusions Atorvastatin combined with Yiqi Yangyin prescription can effectively improve the inflammatory reaction, hemodynamics and renal function in the patients with DN. And the high-dose Atorvastatin provides the most significant improvement without increasing the adverse reaction.