Objective To investigate the clinical effect of Sihongqubantang combined with spine carding treatment on qi stagnation and blood stasis type chloasma . Methods Totally 78 cases of qi stagnation and blood stasis type chloasma treated in 230 hospital of Dandong city from January 2015 to January 2017 were selected. They were divided into observation group (n = 39) and control group (n = 39) by random number table method. The observation group received Sihongqubantang combined with spinal carding treatment, the control group received routine western medicine. After treatment, the efficacy and treatment safety of the two groups were evaluated. Results ① The total effective rate of the two groups was statistically significant different (χ2 =5.186, P = 0.023), the clinical efficacy of the observation group was higher than that of the control group. ② The skin moisture and elasticity in observation group were statistically significant higher than those of control group after treatment (t = 8.298 and 6.651, all P = 0.000). ③ Serum nitric oxide (NO) level in observation group was lower than control group, while superoxide dismutase (SOD) level in observation group was higher than control group after treatment (t =4.585 and 7.389, all P = 0.000). ④ The incidence of adverse reactions after treatment in observation group was statistically significant lower than control group (χ2 = 5.014, P = 0.025). Conclusion The clinical effect of Sihongqubantang combined with spine carding treatment on qi stagnation and blood stasis type chloasma is remarkable, which can significantly improve lesion area and the skin color of the patients, improve the activity of serum SOD, decrease the serum level of NO and be antioxidant. The treatment is safe and has high clinical application value.