Objective To observe the effect of E-An video laryngoscope tracheal intubation in the lateral. Methods A total of 70 patients undergoing selective operation position were randomly divided into lateral intubation group (group C, n = 35) and supine position intubation group (group Y, n = 35). Patients in group C were placed in the lateral position and then anesthetized intubation. In group Y, the anesthesia was intubated and then placed in the lateral position. All patients were intubated with an easy-to-use video laryngoscope (E-An-II), and the intubation time and insertion were recorded. Number of tubes, intubation injury, time and number of people required to position, and waiting time after anesthesia. Results Both groups were successfully intubated in first-attempt, and there was no statistically significant difference in intubation time and intubation injury (P > 0.05); the average number of people in group C was 1.5 people, the average position saving time was 5 minutes and 11 minutes of anesthesia, the difference was statistically significant (P < 0.05). Conclusions An experienced anesthesiologist uses a E-An video laryngoscope to intubate in the lateral position, which is as convenient and safe as the supine position, and significantly saves manpower for position, saves time, improves operating room efficiency, and is also suitable for maintaining lateral position. Special patient for intubation.