Objective To explore the relationship between laboratory blood parameters and recurrence of vasovagal syncope (VVS) in children. Methods The clinical data of 82 children with vasovagal syncope in our hospital from January 2014 to January 2017 were analyzed retrospectively. 21 cases of children relapsed within 1 year after treatment were divided into the recurrence group, and the other 61 children without recurrence within 1 year after treatment were divided into non-recurrence group. Univariate and Logistic multivariate were used to analyze relapse-related factors in children with VVS. Results The results of univariate analysis showed that the body mass index (BMI), hemoglobin (Hb), platelet count (PLT) and mean erythrocyte hemoglobin (MCH) in recurrence group were higher than those in non-recurrence group, but BMI was lower (P < 0.05). The proportion of children with motion sickness history and positive family history in recurrence group was higher than that in non-recurrence group, and the difference was statistically significant (P < 0.05). Logistic multivariate analysis showed that high Hb, high PLT, high MCH, history of motion sickness and positive family history were risk factors of recurrence of children with VVS (P < 0.05). Conclusions Increasing Hb, PLT and MCH are the risk factors of recurrence of children with VVS. The children with motion sickness and positive family history have high risk of recurrence. To improve the prognosis, we should strengthen the surveillance of these children.