Objective To study the expression and clinical significance of miR-599 and bromodomain-containing protein (BRD4) in papillary thyroid carcinoma (PTC). Methods A total of 52 PTC patients who received thyroid surgery in our hospital from May 2005 to March 2007 were selected. Totally 41 cases of para-cancer normal tissue as well as cancerous tissues were utilized for determination of expression of miR-599 and BRD4. Relationship between the expressions of miR-599 and BRD4 and clinicopathological features was analyzed. Results The relative expression of miR-599 and BRD4 in cancerous tissues was significantly different when compared with adjacent normal tissues (P?