Objective Migraine is a highly prevalent and disabling neurological disorder associated with a wide range of psychiatric comorbidities, which may affect their family members. However, to date, it is not known how anxiety / depression in migraine patients and their spouse effect their satisfaction of consultation in outpatient clinic. We assessed the scores of depression and anxiety in patients with migraine and his or her spouse / domestic partner and compared national average value with hypertension patients to determine whether patients who report higher levels of anxiety have lower levels of satisfaction after consultation. Methods Patients with migraine were ascertained from a clinic-based samples from April 2015 to August 2017. Depression and anxiety were assessed by the Zung Self-Rating Depression Scale (SDS) and Zung Self-Rating Anxiety Scale (SAS). We also assessed his or her spouse / domestic partner and the patients with hypertension during this period. After consultation, the patients and their spouse / domestic partner were questioned by a satisfaction score. Results The anxiety and depression levels of the patients with migraine were significantly higher than that of the national norm and patients with hypertension (P??0.05), however their anxiety levels were higher than national norm (P??0.05). There is no relationship between depression and satisfaction score in both patients with migraine and their spouse (P?> 0.05). Conclusion The incidence of depression and anxiety of middle-aged female migraine patients with long course of disease is higher, and the satisfaction of treatment is also lower. During the treatment period, doctors need to pay attention to it, and the anxiety of their family members is also increased, and intervention is needed if necessary.