Objective To investigate the relationship between the expression of Cell division cyclin 25 homologous protein C (Cdc25C) and radiotherapy resistance in squamous cell carcinoma of the esophagus. Methods Retrospective analysis was performed on 50 patients with esophageal squamous cell carcinoma who received radical radiotherapy. The expression level of Cdc25C in esophageal carcinoma before radiotherapy was detected by immunohistochemical, and the relationship between Cdc25C expression and short-term efficacy and survival prognosis of patients with esophageal carcinoma after radiotherapy was analyzed. Result The survival rate of patients in the high expression group and the low expression group was significantly different, and the survival rate of patients in the high expression group of Cdc25C was lower than those in the low expression group (P?