Objective To compare KDSS (Kawasaki disease shock syndrome) with KD (Kawasaki disease) in clinical manifestation, characteristic of laboratory examination and therapy that make convenient for recognition of KDSS. Method A total of 45 cases of KD related diseases hospitalization in our hospital including 15 KDSS and 30 KD were retrospectively analyzed through characteristic of clinical manifestation, laboratory examination and therapy. Results The time of hospital stay was longer in KDSS than KD (P??0.05). 14 cases of KDSS were interrupted by vasoactive drugs, 5 by albumin and 15 by glucocortiocoid more than KD with significant difference (P?