Objective To retrospectively analyze the clinical data of acute poisoning cases in emergency intensive care unit (ICU) of our hospital, and to summarize the experience of diagnosis and treatment. Methods From February 2014 to August 2018, 310 cases of acute poisoning were collected in the emergency ICU ward of our hospital. They were divided into survival group and death group. Among them, 164 were male and 146 were female, with an average age of (39.2?±?4.7) years. The prognosis, severity of poisoning, risk factors of poisoning, treatment methods and organ function damage were analyzed. Results There were 291 cases in survival group and 19 cases in death group. The severity score of poisoning in death group was significantly higher than that in control group (P?