Objective To investigate the inhibitory effect of curcumin nicotinatel on IL-1β, IL-18 production in macrophage exposed to radiation. Methods Macrophage were divided into non-treated control group, irradiated group and curcumin nicotinate treated group where curcumin nicotinate with different dosage of 1.0?μmol/L, 3.0?μmol/L and 9.0?μmol/L was administrated to macrophage before irradiation. The expressions of IL-1β, IL-18 protein were detected using Western blotting. Results Compared with the control group, the expression levels of IL-1β and IL-18 proteins in the curcumin niacin group were significantly increased (P?