Objective To detect the expression of MRN complex in oral squamous cell carcinoma and analyze its correlation with the pathological features. Methods Fifty patients with oral cancer radical surgery at the Affiliated Stomatological Hospital of Guangxi Medical University (from January 2016 to June 2017) were enrolled as observation group, and the control group consisted of 50 cases of paracancerous or benign diseases. The expression of MRE11, RAD50 and NBS1 was detected by immunohistochemistry. Results The positive expression rates of MRE11, RAD50 and NBS1 in the observation group were 34%, 38% and 60%, respectively. The control group was 56%, 60% and 32% respectively. The difference between the two groups was statistically significantly (P??0.05). Conclusions The positive expression rates of MRE11, RAD50 and NBS1 were different in OSCC and control tissues. NBS1 is related to the degree of OSCC differentiation, lymphnode metastasis and clinical TNM stage.