Objective To study the effect of albumin combined with low dose furosemide on pulmonary function and general anesthesia recovery in patients with extensive burns. Methods Forty patients with extensive burns, aged 23 to 67 years, of American Society of Anesthesiologists physical status II or III, with preoperative serum albumin less than 35?g/L, scheduled for skin grafting surgery under general anesthesia, were divided into either observation group or control group (n?=?20). The observation group adopted restrictive infusion method. At the beginning of operation, albumin 10 g/h was continuously pumped and 5mg furosemide was given. The crystal liquid was continuously infused at 300 to 400?m/h without using colloid. The red blood cells and plasma were used when necessary. The control group was given conventional infusion. Before the induction of anesthesia, the 500?ml crystal solution was given to expand blood volume. In the operation, the crystal, colloid fluid or blood were supplemented according to central venous pressure, blood pressure and blood loss. The oxygenation index (OI), lactic acid (Lac), tidal volume (VT), peak airway pressure (Ppeak), mean airway pressure (Pmean) lung dynamic compliance (Cdyn), total volume of infusion and recovery time of general anesthesia were compared between the two groups. Results In the control group, the OI and Cdyn were lower, and the Ppeak, and Pmean was higher at the end of operation than before operation (P??0.05). Compared with the control group, the OI and Cdyn of the observation group were higher at the end of operation, and the Ppeak was lower (P?