Objective To explore the protective treatment of swollen snake bite swollen wounds, to prevent the occurrence of skin ulceration and ischemic muscle contracture, and to save limbs and functions. Methods A total of 168 cases of snake bites (toes) from April 2017 to November 2018 were selected, including 76 cases from April to November 2017 (group A, n?=?76) were retrospectively analyzed, and the other 92 patients from April to November 2018 were prospectively studied, treated with simple wound diamond-shaped decompression and open drainage (group B, n?=?55) and wound diamond-shaped decompression and incision VSD vacuum suction drainage (group C. n?=?37). The swelling time of the affected limb, local ulceration and necrosis at the distal end, residual dysfunction of the joint, wound infection and finger (toe) were recorded and compared. Results There were no significant differences in gender, age, swelling degree and classification of the three groups (P?>?0.05). There were significant differences in hospitalization time, swelling regression time, wound infection, flap necrosis and dysfunction among 3 groups (P?