Objective To evaluate the the relationship between MAD parameters and serum Hcy, vWF and CysC levels in patients with coronary heart disease by ultrasound. Methods A total of 100 patients with CHD were selected from January 2017 to January 2019. According to the clinical manifestations, serum enzyme changes and electrocardiogram results, the patients were divided into group A (angina pectoris, 46 cases) and group B (myocardial infarction, 54 cases). At the same time, 60 cases of healthy physical examination were selected as the control group. The MAD parameters of three groups were measured by color Doppler ultrasound diagnostic instrument, and the levels of serum Hcy, vWF and CysC were measured by enzyme-linked immunosorbent assay (Elisa). The correlation between MAD parameters and the level of serum Hcy, vWF and CysC was analyzed by Pearson test. Results Compared with control group, the parameter values of MAD in group A and group B were significantly decreased (P?