Objective To compare the efficacy of posterior single-door laminoplasty with anterior intervertebral space decompression, bone grafting and internal fixation in the treatment of multilevel cervical spondylotic myelopathy. Methods From January 2015 to December 2017, 64 patients with multilevel cervical spondylotic myelopathy admitted to our hospital were selected and divided into observation group and control group according to random number table method, 32 cases in each group. In the observation group, anterior cervical intervertebral space decompression, bone grafting, fusion and internal fixation were performed, while in the control group, posterior single-door laminoplasty was performed. The clinical data was compared between two groups. Results The bleeding volume, drainage volume and hospitalization time in the observation group were less than those in the control group (P?