Objective To analyze the respiratory function and HRCT quantitative indicators in patients with different HRCT phenotypes, and to provide reference for the selection of clinical treatment programs for this disease. Methods From January 2018 to December 2018, 80 patients with COPD were admitted to Xinhua Hospital Affiliated to Shanghai Jiao tong University School of Medicine. All patients underwent blood routine test and blood gas test, PFT examination and HRCT examination. Pulmonary function indexes, HRCT quantitative indicators (including airway wall quantitative indicators and emphysema quantitative indicators), airway wall quantitative indicators including the bronchial lumen diameter (LD), wall thickness (WT), tube wall area percentage of the total area of the bronchial section (WA%) and wall thickness /pulmonary artery diameter (WT/PA), Emphysema quantitative indexes including the total lung volume (TLV), the total volume of emphysema (TEV) and emphysema index (EI) were Measured. According to HRCT images with/without emphysema or thickening of bronchial wall, patients were divided into phenotype A, E and M. Blood routine test, blood gas, lung function and HRCT quantitative indicators were compared in patients with three phenotypes. Results There were 50 cases with phenotype A (62.50%), 16 cases with phenotype E (20.00%) and 14 cases with phenotype M (17.50%) in this group of patients with COPD. The differences of blood gas indexes PaCO2, PaO2 and SaO2 in patients with COPD with different HRCT types were statistically significant (P?