Objective To compare the clinicopathologic features and prognosis of patients between right-sided colon cancer (RCC) and left-sided colon cancer (LCC) after radical resection. Methods A retrospective analysis of clinical data was made among cases of colon cancer undergoing radical surgeries at Harrsion International Peace Hospital from January 2010 to December 2013. The patients were divided into RCC group (n?=?104) and LCC group (n?=?92). The differences of clinicopathologic features and prognosis of patients in different group were compared. Overall survival (OS) and disease-free survival (DFS) were analyzed with the Kaplan–Meier method, and the difference test was carried out with Log-rank test. Univariate and multivariate analyses were performed with Cox regression model. Results Data of RCC exhibited older ages, higher incidence of poor differentiation or mucinous adenocarcinoma, more harvested lymph nodes than LCC. Weight loss and anemia occupied a high proportion in the first symptoms for the patients with RCC, as hematochezia and changes in bowel habits presented in patients with LCC. Median follow-up time was 69 months. The 5-year disease-free survival (DFS) rates for patients with RCC and LCC were 53.8% and 70.5% (P?>?0.05), while the 5-year overall survival (OS) rates were 65.4% and77.2% (P??0.05), while the 5-OS rates were 74.6% and 78.0% (P?>?0.05); in stage III cancers, the 5-DFS rates for patients with RCC and LCC were 36.6% and 65.1% (P?< 0.05), while the 5-OS rates were 48.8% and 71.4% (P?