MicroRNAs are a class of non-coding single-stranded small RNA molecules that are about 19-25 nucleotides in length and are involved in the regulation of post-transcriptional levels of genes. They are widely found in plants, animals and viruses. The number of miRNAs is large, and their biological functions are very complex. Many miRNAs play a role in promoting or suppressing cancer in the progression of malignant tumors. MicroRNA- 152 is one of the more closely concerned miRNAs in recent years. It acts as a tumor suppressor in many malignant tumors. It is significantly reduced in the three major genital malignant tumors of gynecology: endometrial cancer, ovarian cancer and cervical cancer. Now we review the current research status between miR-152 and the three major genital malignant tumors of gynecology.