Objective To determinethe expression of human angiogenic factor with G patch and FHA domains 1 (AGGF1) in cervical carcinoma, and to investigate its relationship with the prognosis of cervical carcinoma. Methods Immunohistochemistry was performed to detect AGGF1 level in the cervical cancer tissues and pericancerous tissues of 60 cases, and the relationship between the expression of AGGF1 and prognosis of the patients was analyzed. Results The expression of AGGF1 in the cervical carcinoma tissues was significantly higher than that in the pericancerous tissues (P < 0.05). The survival rate of the patients with high AGGF1-expression was significantly lower than that of the patients with low AGGF1-expression (P = 0.004). The Cox model analysis revealed that AGGF1 expression was an independent biomarker for prediction of the survival of cervical carcinoma patients. Conclusions High expression of AGGF1 predicts poor prognosis in cervical carcinoma patients. AGGF1 can be used as an independent factor to predict postoperative survival of patients with cervical cancer.