Objective To observe the effect of plasma cryoprecipitate on the repair of rabbit infective wounds, and then explore the mechanism of the cryoprecipitate in promoting the healing of rabbit infective wounds. Methods Twelve healthy adult rabbits, according to the improved Fu Xiaobing full-thickness skin defect method, were made into wound infectious animal surface ulcer model, and then were treated respectively with the cryoprecipitate, Kangfuxin solution, MEBO or Vaseline gauze dressing. On the 3rd, 7th, 12th and 17th day of treatment, the microvascular density (MVD), healing rate, new epithelial coverage rate and TGF-β1 expression of the wound were tested. Results On the 3rd day of treatment, MVD rose in all the groups; on the 3rd and 7 th day, MVD in the cryoprecipitate group was statistically different from that of the rest three groups (χ2 3d = 15.151, χ2 7d = 27.837;P = 0.002 and 0.000); after the 12th day, new blood vessels gradually reduced. The wound healing rate and the new epithelial coverage rate in the cryoprecipitate group were higher than those in the Kangfuxin solution group and the Vaseline group (P < 0.05). The wound healing time in the cryoprecipitate group was significantly shorter than that in the other groups (H = 11.169, P = 0.011). TGF-β1 expression in the cryoprecipitate group was higher than that in the other three groups (χ2 3d = 17.400, χ2 7d = 21.969; P = 0.001 and 0.000), and maintained high level during the entire repair process. Conclusions The cryoprecipitate can increase MVD of the wound, promote the new epithelial coverage, and accelerate wound healing through up-regulation of TGF-β1 expression in the wounds.