Objective To explore the effect of high frequency deep hyperthermia combined with GP regimen chemotherapy in the treatment of advanced ovarian cancer with peritoneal effusion. Methods A total of 60 cases of OCC treated with cytoreductive surgery were divided into control group (GP intraperitoneal chemotherapy) and observation group (high frequency deep hyperthermia plus GP intraperitoneal chemotherapy) randomly. The shortterm efficacy, toxic and side effect, quality of life and the serum levels of HE4, CA125 and CEA were compared. Results The short-term efficacy was significantly higher in the observation group than that in the control group(P < 0.05). Both2 groups had no significant difference. Life quality improvement rate of the observation group was significantly higher than that of the control group (P > 0.05). KPS score of the observation group was significantly higher than that of the control group (P < 0.05) after treatments. Serum levels of HE4, CA125 and CEA were significantly lower in the observation group than those in the control group after treatment (P < 0.05). Conclusion High frequency hyperthermia plus GP intraperitoneal chemotherapy was effective and safe for old OCC patients, which can improve the quality of life and decrease the serum levels of HE4, CA125 and CEA. two groups had no serious toxic and side effect. Incidence of toxic and adverse reaction of the 2 groups had no significant difference. Life quality improvement rate of the observation group was significantly higher than that of the control group (P > 0.05). KPS score of the observation group was significantly higher than that of the control group (P < 0.05) after treatments. Serum levels of HE4, CA125 and CEA were significantly lower in the observation group than those in the control group after treatment (P < 0.05). Conclusion High frequency hyperthermia plus GP intraperitoneal chemotherapy was effective and safe for old OCC patients, which can improve the quality of life and decrease the serum levels of HE4, CA125 and CEA.