Objectives To evaluate the correlation of hyperhomocysteinemia, insulin resistance and hypersensitivity C-reactive protein (hs-CRP) with prehypertension. Methods Sixty prehypertensives and 32 normotensives were recruited according to Seventh Report of the Joint National Committee on Prevention,Detection, Evaluation and Treatment of blood pressure (JNC 7) guidelines. Serum homocysteine, vitamin B12, folate,insulin, hs-CRP and lipid profile were analyzed. Independent t-test was carried out in the two groups and Pearson correlation analyses were carried out between various parameters and systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively. Results Cardiovascular risk factors like serum homocysteine, insulin resistance and inflammatory marker hs-CRP were significantly increased in prehypertensives. Total cholesterol, TG, LDL-C and VLDL-C were significantly increased in prehypertensives compared with those in normotensives. Serum homocysteine correlated positively with SBP while vitamin B12 and folate correlated negatively with it. Conclusion Homocysteine, insulin resistance, and hs-CRP have correlation with prehypertension and can increase the risk of cardiovascular disease in the subjects.