Objective To follow up effect of the transcatheter closure of perimembranous ventricular septal defect (PMVSD) children with modified doubel-disk occluder device. Methods 52 cases of PMVSD children who received interventional treatment using domestic occluder monitored by X-ray and ultrasound from July 2011 to December 2014 were analyzed. The therapeutic effects were evaluated immediately after the implantation by angiography of left ventricular and aortic, and ultrasound cardiogram. 1 days, 1 month, 3 months, 6 months, 12 months, 24 months follow-ups were performed to  evaluate the short-term, mid-term and long-term efficacy, in which transthoracic echocardiography was used to diagnosis of shunt and regurgitation and to detect cardiac size and function, and electrocardiogram was performed to inspect the. Arrhythmia. Results Of the 48 successfully treated patients, 4 cases failed to be implanted, the success rate was 92.31%. Follow-up of 48 patients were completed, and the median follow-up time was 23.6 months (12～48 months). Postoperative trace or small residual shunt immediately were found in 4 patients so that the residual shunt rate was 8.33 %. Then postoperative residual volume reduced gradually1 months later, 2 cases of shunt disappeared completely, but there were still 2 cases existing small quantity residual, and the residual shunt flow rate was 4.17%. There were totally 6 cases of atrioventricular block, 5 of which suggested right bundle branch block, and with 1 case having left bundle branch block and with 1 case occurring borderline idioventricular rhythm. The incidence of arrhythmia was 14.58 %. There were 2 new cases of trace or a small amount of reflux. No shedding of occluder, infective endocarditis, and thromboembolism occurred. The cardiac size on postoperative 12 month and 24 month significantly increased compared with that of 1 day (P ＜ 0.05), which were within the normal range. The cardiac function on postoperative 12 month, 24 month and1 day were found no significantly difference to the preoperative condition (P ＞ 0.05). Conclusion Transcatheter domestic occluder in transcatheter closure of perimembranous ventricular septal defect in children was successful at a comparatively high rate, and appeared a low incidence of postoperative complications, and the long-term curative effect was reliable, worthy of clinical application.