Objective To study the correlation of the blood oxygenation level-dependent (BOLD) imaging measurements with glomerular filtration rate (GFR) and Katafuchi scores in IgA nephropathy. Methods Thirty-five patients with IgA nephropathy and twenty healthy volunteers were enrolled in this study. All of the subjects underwent studies on 3.0T MR scanner to obtain the BOLD imaging measurements. The GFR was calculated with 99Tcm-DTPA scintigraphy. The grades and the pathological damage scores of IgA nephropathy were evaluated according to the Lee classification and the Katafuchi system. The R2* values were compared between the control group and IgA nephropathy groups of different grades. The correlation between the R2* values and GFR was analyzed. The correlation between the R2* values and Katafuchi scores was analyzed. Results The renal cortical R2* values were lower than the medulla values in both the control and IgA nephropathy groups (P < 0.05). There were statistically significant differences in renal cortical and medulla R2* values between the control group and each of the IgA nephropathy subgroups (P < 0.05). But there was no significant difference in renal cortical and medulla R2* values between the IgA N I group and the control group (P > 0.05). There was a negative correlation between the renal cortical and medulla R2* values and the GFR (P < 0.05). A positive correlation was found between the renal cortical and medulla R2* values and the Katafuchi scores (P < 0.05). Conclusions The blood oxygenation level-dependent imaging was applicable on IgA nephropathy, which could be used for assessing the renal filtration function and the pathological damage. However, BOLD imaging lacks sensitivity to early renal disease.