Objective To discuss the clinical value of continuous bispectral index (BIS) monitoring in patients with sepsis-associated encephalopathy. Methods Using random method, 116 sepsis patients treated in our hospital from Apr. 2011 to Apr. 2014 were divided into septic-encephalopathy (SAE) group and non-septic encephalopathy (non-SAE) group. The differences in BIS, procalcitonin (PCT), S100β protein, Glasgow coma (GCS) score, and acute physio-
logy and chronic health evaluation scoring system (APACHE-II) score were compared between the two groups. The correlations of BIS with GCS score and APACHE-II score were analyzed with Pearson correlation analysis. Results The PCT value [(8.453 ± 3.442) μg/L] and S100β protein value [(0.775 ± 0.356) μg/L] in the SAE group were significantly higher than those [(4.775 ± 2.874) μg/L and (0.146 ± 0.096) μg/L respectively] in the non-SAE group. BIS of the SAE patients was significantly correlated with GCS and APACHE-II (r = 0.754 and -0.657 respectively), while such correlations were not found in the non-SAE patients. In addition, in the two groups the indexes were significantly different between the patients with different treatment outcomes (P < 0.05). Conclusions Implementation of continuous BIS monitoring to patients with sepsis is conducive to early diagnosis of sepsis-associated encephalopathy and plays a role in predicting prognosis. At the same time BIS has good correlations with GCS and APACHE-II; combined with PCT and S100β expression levels, it helps to accurately assess the patient's condition.