Objective To study the expression level of FRY protein in breast carcinomas of various degree of malignancy and its relationship with clinical pathological parameters. Methods One hundred and four cases of breast carcinomas were studied using immunohistochemical method, among which 11 cases had fibrocystic breast disease and 93 cases had invasive ductal carcinomas of breast. The expression level of FRY protein was determined, and the possible relationships between the FRY expression and a number of clinical pathological parameters were investigated. Results There was a significant difference in the positive rate of FRY expression between the fibrocystic breast disease cases and the breast invasive ductal carcinoma cases (90.9% vs 54.8%, P < 0.05). In the breast invasive ductal carcinomas, FRY expression was positively correlated with histological grades, TNM stages, tumor diameter and PR expression (P < 0.05). Conclusions The expression of FRY protein is strongly correlated with the malignant degree of breast carcinomas; the higher the malignancy of the carcinomas, the lower the expression level of FRY protein. Meanwhile, FRY expression is also related to progesterone receptor level in the body.