Objective To evaluate the protective activity of SchA derivant DDB on the UVB-induced skin damage and explore its mechanism. Methods The Anti-oxidation activity against reactive oxygen species (ROS) including superoxide anion radical(O2-) was investigated. Methyl thiazolyl tetrazolium (MTT) assay was used to examine the effect of DDB or UVB on HaCaT and Fb cells' viability and its protective effect from UVB's damage. UVB-induced cells apoptosis was visualized with Giemsa stain. Anti-oxidative capacity of the drugs was evaluated by dichlorodihydrofluorescein diacetate (DCFH-DA) assay. Results In this study, the topical application of DDB after UVB irradiation  was found to decrease UVB-induced oxidation damage, the drug had a highly activity of superoxide anion radical(O2-). Through MTT assay, we found that DDB  was found had no damage to cells. Meanwhile, we also find that DDB can decrease human melanoma cell's production.Through Giemsa stain, we visualized that the drug can inhibite UVB induced HaCaT cell death. Conclusions In a word, DDB may be useful in antiphotoaging agents in the treatment of UVB irradiation.