Objective To investigate the clinical effect of Biyuan Tongqiao particles in combination with Fexofenadine hydrochloride in the treatment of allergic rhinitis (AR) and its effects on the levels of serum TNF-α, IL-4 and IL-13. Methods In this study, 140 patients of AR who received therapy in our hospital from January 2014 to February 2015 were selected as research objects. According to random number table, the patients were divided into two groups equally. Besides conventional treatments, the control group was treated with Fexofenadine hydrochloride, while the observation group was treated with Biyuan Tongqiao particles in combination with Fexofenadine hydrochloride. Then, the curative efficacy, scores of clinical symptoms, and the levels of serum TNF-α, IL-4 and IL-13 were compared. After 6-month follow-up, the recurrence rate was compared between the two groups. Results After treatment, the observation group had a total therapeutic efficiency rate of 95.7%, which was statistically higher than that of 84.3% in the control group (P < 0.05). The scores of sneeze, nasal mucus, nasal congestion and nasal itching in the observation group were statistically lower than those of the control group (P < 0.05). The levels of serum TNF-α, IL-4 and IL-13 in the observation group were statistically lower than those of the control group (P < 0.05). After 6-month follow-up, the recurrence rate in the observation group was 7.1%, which was statistically lower than 20.0% in the control group (P < 0.05). Conclusions Biyuan Tongqiao particles in combination with Fexofenadine hydrochloride is effective for the treatment of AR, which has a high effective rate. And it can significantly improve clinical symptoms and alleviate inflammatory reaction with low recurrence rate.