Objective To explore the clinical effect of electroacupuncture combined xuesaitong acupoint injection for treatment of cervical spondylotic radiculopathy. Methods Ninty patients with the diagnosis of cervical spondylotic radiculopathy between Jan 2013 and Jan 2015, were randomly divided into electroacupuncture group, acupoint injection group and combined treatment group. The electroacupuncture group received electroacupuncture treatment at fengchi, dazhui, jianjing, waiguan and coresponding jiaji points. The acupoint injection group adopted xuesaitong acupoint injection into coresponding jiaji points. The combined treatment group received acupoint injection after electroacupuncture treatment. Quantitative score of signs and symptoms and visual analogue scales (VAS) were applied to evaluate the curative effect. Serum levels of TXB2 was detected by radioimmunoassay. Results The effective rate of combined treatment group was higher than the other two groups (P = 0.003 and 0.008), whilst the acupoint injection group was higher than the electroacupuncture group (P = 0.012). After treatment, the scores of signs and symptoms of three groups were elevated, and the combined treatment group was higher than the other two groups (P = 0.008 and 0.009), while the acupoint injection group was higher than the electroacupuncture group (P = 0.037). The VAS scores of three groups were declined after respective treatment. The combined treatment group showed lower score than the other two groups (P = 0.002 and 0.012), and the acupoint injection group was lower than the electroacupuncture group (P = 0.017). The serum levels of TXB2 of the three groups were similar with the results on the VAS score. Conclusions Electroacupuncture combined acupoint injection therapy showes superiority to electroacupuncture and acupoint injection therapy, acupoint injection therapy is superior to the electroacupuncture therapy. Moreover, the treatment effects of the three methods may be associated with serum levels of TXB2.