Objective To investigate the influence of the coexpression of HIF-1α and COX-2 on the prognosis of patients with cervical cancer in stageⅠ and stage Ⅱ and the possible functional mechanism. Methods The coexpressions of HIF-1α and COX-2 were detected in 71 cases with cervical cancer by immunohistochemical. The levels of HIF-1α mRNA and COX-2 mRNA were detected by RT-PCR. Chi-squared test was used to analyze the differences of survival rate from one year to three year in different groups; KM survival analysis was used for the survival time in different groups; correlation analysis was used to analyze the correlation between protein and mRNA level. Results The survival rate of three year in the group of coexpression of HIF-1α and COX-2 was significantly lower than that in the non-coexpression group (P < 0.05). The survival time in the group of coexpression of HIF-1α and COX-2 was significantly shorter than that in the non-coexpression group (P < 0.05). There was a positive correlation between the HIF-1α protein level and the COX-2 mRNA level in the patients with cervical cancer in stageⅡ (rs= 0.594, P < 0.05). Conclusions The prognosis is poorer in the group of coexpression of HIF-1α and COX-2 of patients with cervical cancer in stage Ⅰ and stage Ⅱ than the non-coexpression group. The HIF-1αprotein may upregulate the level of COX-2 mRNA.