Migraine is a clinically common, chronic and disabling neurological disorder, and more than half of sufferers have migraine attacks that interfere with their normal lives. In recent years, a large number of studies have shown that there is a certain association between migraine and patent foramen ovale (PFO), but the causal relationship between the two is still controversial due to the high incidence of PFO and the unknown pathophysiological mechanisms that triggers migraine attacks via PFO. Moreover, whether PFO closure is an effective treatment for migraine has become a hot topic. This review focuses on the correlation between PFO and migraine, the possible pathogenesis and the efficacy of PFO closure in the treatment of migraine.