Objective To observe the curative effect of Qingzi Mixture combined with routine western medicine on Henoch-Schonlein purpura (HSP).Methods A total of 140 children with HSP who were admitted to our hospital from March 2017 to February 2019 were enrolled. They were divided into treatment group and control group by random number table method, with 70 cases in each group. The control group was given routine western medicine alone, while the treatment group was given Qingzi Mixture on the basis of control group. The two groups were continuously treated for 14 d. The clinical curative effect and time to symptom disappearance in both groups were observed. The blood routine, coagulation function, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and immune function of children with HSP were measured before and after treatment. The occurrence of adverse reactions was recorded.Results The total response rate of treatment group was higher than that of control group (88.57% vs. 77.14%) (P < 0.05), while the time to disappearance of skin rash and abdominal pain and the time to remission of digestive and articular manifestations in treatment group were shorter than those in control group (P < 0.05). After treatment, the levels of ESR, IgA, IgG, WBC, PLT, D-dimer and CRP in treatment group were lower than those in control group (P < 0.05).Conclusions Qingzi Mixture combined with western medicine is effective for the treatment of HSP in children by improving clinical symptoms and relevant laboratory indicators.