Objective To evaluate the efficacy and safety of anti-inflammatory treatments combined with Xuefuzhuyu Tablet for facial erythema of rosacea.Methods Sixty-two patients with rosacea visited our department from December 2018 to November 2019 were randomly divided into the treatment group (n = 32) and control group (n =30). The control group was given anti-inflammatory treatments alone, while the treatment group was additionally given Xuefuzhuyu Tablet on the basis of the anti-inflammatory therapy. The clinical efficacy was evaluated blindly by two specialists.Results There was no difference in the gender composition, age, or the disease duration between the two groups (P > 0.05). The subjective scores and efficacy index of the treatment group were greater than those of thecontrols (P < 0.05). In addition, the clinical effective rate was higher in the treatment group compared with the control group (P < 0.05).Conclusions The combination of Xuefuzhuyu Tablet based on the anti-inflammatory therapy is effective for improving facial erythema in rosacea.