Narcolepsy is a chronic sleep disorder that usually develops during adolescence and lasts for a lifetime. The clinical manifestations of narcolepsy are irresistible somnolence at the daytime, cataplexy, sleep paralysis, and hypnagogic hallucinations, where the underlying mechanism is the lack of hypocretin. Epilepsy is one of the common neurologic disorders and its clinical manifestations are complex and diverse. When epilepsy is comorbid with narcolepsy, it will be more confusing and more likely to be misdiagnosed. Therefore, this article summarizes the clinical characteristics of narcolepsy and the symptoms of the comorbidity of narcolepsy and epilepsy, so as to reduce the rate of diagnostic errors of the disease.