Parkinson's disease (PD) is a clinically common degenerative disease of the central nervous system. The main pathological mechanism is the degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the loss of dopamine transmitters in the striatum. The causes are mainly genetic factors and environmental factors, The disease mainly causes a series of motor symptoms such as resting tremor, bradykinesia, and muscle rigidity. However, the pathogenesis of PD is not clear, The research found that it may be related to mitochondrial dysfunction, oxidative stress, protein changes and inflammation. Current research has found that microglia are closely related to inflammation response, And in the pathological process of PD, excessive activation of microglia (MG) is the pathophysiological basis of PD pathogenesis. Studies have reported that elevated serum inflammatory factors are related to PD, which can be used to diagnose PD early and predict disease prognosis. At present, anti-inflammatory treatment has become a new research hotspot in PD. More and more studies have found that anti-inflammatory drugs can prevent and treat Parkinson's disease. This article mainly introduces the inflammatory mechanism of PD, related inflammatory factors and the progress of anti-inflammatory drugs.