Objective To investigate the expression of soluble granule membrane protein CD62P (s-CD626P), inflammatory factor, and coagulation index in patients with multiple trauma and sepsis, and to analyze the relationship between them.Methods A total of 102 patients with multiple injuries complicated with sepsis and 100 healthy persons who received physical examination at the same time were selected as the observation group and the control group respectively. The levels of s-CD62P, inflammatory factors (TNF-α, hs-CRP, IL-6, PCT) and coagulation indexes (PT, APTT, PLT, D-D) were measured. The relationship between s-CD62P, inflammatory factors, and coagulation indexes was analyzed.Results The plasma s-CD62P level in the observation group was (223.05 ± 69.14) ng/mL, and that in the control group was (96.25 ± 31.54) ng/mL. The level of s-CD62P in the observation group was higher than that in the control group (P < 0.05). The levels of TNF-α, hs-CRP, PCT, IL-6, PT, APTT, and D-D water in the observation group were higher than those in the control group, and the levels of PLT were lower than those in the control group (P < 0.05). The correlation analysis showed that s-CD62P was positively correlated with TNF-α, hs-CRP, IL-6, and PCT (P < 0.05), while s-CD62P was positively correlated with Pt, APTT, and D-D (P < 0.05). TNF-α, hs-CRP, IL-6, and PCT were positively correlated with Pt, APTT, and D-D, and negatively correlated with PLT (P < 0.05).Conclusion The increased expression of s-CD62P in the plasma of patients with multiple trauma and sepsis indicates that the endothelial cells are seriously damaged. The expression of s-CD62P is closely related to inflammatory factors and coagulation indexes, which may induce the formation of inflammatory coagulation network in sepsis.