Objective To investigate the curative effect of stent retriever thrombectomy combined with aspiration thrombectomy in the treatment of elderly patients with acute large vessel intracranial occlusion and its influences on the hemodynamics and neurological function.Methods A total of 62 elderly patients with acute large vessel intracranial occlusion in Suzhou First People's Hospital and the Affiliated Hospital of Guizhou Medical University from October 2016 to October 2019 were selected and divided into observation group (31 cases) and control group (31 cases) according to the random number table method. The control group was treated with stent retriever thrombectomy alone, and the observation group was treated with stent retriever thrombectomy combined with aspiration thrombectomy. The time to recanalization of intracranial arteries and veins, the number of thrombectomy attempts, the alterations in China Stroke Scal (CSS) score, Barthel Index (BI) score, and minimum blood flow rate (Qmin) and minimum blood flow velocity (Vmin) of carotid artery between baseline before operation and 3 months after operation, and prognosis of the patients at 3 months after operation were compared between the two groups.Results The time to recanalization of intracranial arteries and veins in the observation group was longer than that in the control group (P < 0.05), and the number of thrombectomy attempts was fewer in the observation group than in the control group (P < 0.05). The differences in CSS score, BI score, Qmin and Vmin between baseline before operation and 3 months after operation were greater in the observation group compared with the control group (P < 0.05). The prognosis of the observation group was better than that of the control group (P < 0.05).Conclusions Stent retriever thrombectomy combined with aspiration thrombectomy is effective in the treatment of elderly patients with acute large vessel intracranial occlusion. It can improve the blood flow and neurological function, and therefore the prognosis of the patients.