Objective To investigate the effect of continuous subarachnoid block (CSA) analgesia on perinatal hemodynamics and safety of mothers and babies in preeclampsia.Methods A total of 196 cases of pre-epilepsy women admitted to our hospital from January 2018 to December 2020 were selected and divided into two groups according to the random number table method, the CSA group (n = 98) and the continuous epidural anesthesia (CEA) group (n = 98). The time of the first and second stages of labor, the delivery methods, the proportion of oxytocin use, the proportion of antihypertensive drugs, the proportion of postpartum hemorrhage, the proportion of headaches after puncture, and the proportion of perinatal skin itching between two groups were compared; blood pressure, visual analog scale (VAS), and hemodynamics (mean arterial pressure (MAP), heart rate, cardiac output (CO), peripheral vascular resistance (SVR)] were compared between the two groups at pre-partum analgesia (T₀), 10 minutes after parturition analgesia (T₁), 30 min after pain (T₂), full uterine opening (T₃), fetal head delivery (T₄).Results The first and second stages of labor in the CSA group were significantly longer than those in the CEA group (P < 0.05). The natural delivery rate and the use rate of oxytocin were significantly higher than those in the CEA group (P < 0.05), and the forceps delivery rate, the use rate of antihypertensive drugs, the headache rate after puncture, and the perinatal skin itching rate were significantly lower than those in the CEA group (P < 0.05). The systolic blood pressure, diastolic blood pressure, VAS score, MAP, CO, SVR of the two groups were different at different time (P < 0.05), between different groups and change trend (P < 0.05). The Apgar score of newborns in the CSA group was significantly higher than that of the CEA group at 1 minute after birth (P < 0.05). There was no difference in the rates of postpartum hemorrhage between the two groups and in the Apgar scores at 5 and 10 minutes after birth (P > 0.05).Conclusion Compared with CEA, CSA analgesia can effectively improve the hemodynamic status of preeclampsia women during labor, reduce labor pain and the use of antihypertensive drugs, and ensure the safety of mothers and babies.