Objective To analyze the timing of epidural analgesia for labor and its effect on labor curve in primiparas from high-land areas.Methods A total of 120 primiparas undergoing epidural analgesia for labor in our hospital from December 2019 to January 2021 were selected. All patients were randomly divided into group A (initiating epidural analgesia right after the onset of parturition with continuous analgesia following the full dilation of the cervix), Group B (initiating epidural analgesia right after the onset of parturition without continuous analgesia following the full dilation of the cervix), Group C (initiating epidural analgesia when the cervix was dilated to 3 to 5 cm with continuous analgesia following the full dilation of the cervix), and group D (initiating epidural analgesia when the cervix was dilated to 3 to 5 cm without continuous analgesia following the full dilation of the cervix). The duration of the first stage of labor, the duration of the second stage of labor, the amount of bleeding within 2 hours after delivery, and the Apgar scores of the newborns at 1 and 5 min were recorded. The pain during labor was evaluated via Visual Analogue Scale (VAS), and the labor curve was plotted.Results The duration of the first stage of labor was shorter in group A and B than that in group C and D, and was the shortest in the group A (P < 0.05). However, there was no significant difference in the duration of the second stage of labor, the amount of bleeding within 2 hours after delivery, or the Apgar scores of the newborns at 1 and 5 min among the four groups (P > 0.05). The group A exhibited the lowest VAS score, as well as the optimal labor curve (P < 0.05).Conclusions Whole-course epidural analgesia for labor can effectively shorten the first stage of labor and improve the labor curve in primiparas from high-land areas.