Pyroptosis is a new type of pro-inflammatory programmed cell death. Two different major categories of pathways, namely the Caspase-1-dependent classical pathway and the Caspase-4/5/11-dependent non-classical pathway, are involved in pyroptosis. Caspase-1-independent classical pathway mediated via NLRP3 inflammasome has been intensively studied and found to play an important role in immune function. Studies have shown that various pro-inflammatory cytokines can be released after pyroptosis, which will further aggravate the inflammation. In addition, pyroptosis is also critical for the development and progression of hepatic diseases. In this paper, we reviewed the molecular mechanism of pyroptosis and the relationship between the pyroptosis of hepatocytes, hepatic stellate cells, and hepatic macrophages, and liver fibrosis.