Objective To compare the effects of intravitreal injection of Conbercept (IVC) on cystoid macular edema secondary to ischemic central retinal vein occlusion (I-CRVO-CME) and non-ischemic CRVO-CME (NI-CRVO-CME).Methods The clinical data of 49 patients with I-CRVO-CME and 54 patients with NI-CRVO-CME in our hospital from January 2016 to January 2020 were retrospectively analyzed. They were assigned to the I-CRVO-CME group and NI-CRVO -CME group. Both groups were treated with IVC and followed up for 12 months after 3 months of treatment. The number of treatments between the two groups were compared. The increase in the number of letters of the best corrected visual acuity (BCVA), the decrease in the macular foveal retinal thickness (CRT), and the decrease in the volume of macular edema (MEV) in the two groups at 3, 6, 9, and 12 months after treatment were compared.Results Compared with the I-CRVO-CME group, the frequency of IVC combined with triamcinolone and IVC combined with laser in the NI-CRVO-CME group were decreased (P < 0.05). BCVA letters increase and CRT reduction were compared between NI-CRVO-CME group and I-CRVO-CME group at 3, 6, 9, and 12 months after treatment, with repeated measures analysis of variance. The results showed: (1) There were differences in the BCVA letter increase, CRT reduction, and MEV reduction between different time points (P < 0.05); (2) There were differences in the BCVA letter increase, CRT reduction, and MEV reduction between the NI-CRVO-CME group and the I-CRVO-CME group (P < 0.05). Compared with the I-CRVO-CME group, the BCVA letter increase, CRT reduction, and MEV reduction were increased in the NI-CRVO-CME group, in which the relative vision and macular edema. (3) The BCVA letter increase, CRT reduction, and MEV reduction between the NI-CRVO-CME group and the I-CRVO-CME group had different trends (P < 0.05). There was no significant difference in the incidence of adverse reactions between the I-CRVO-CME group and the NI-CRVO-CME group (P > 0.05).Conclusion IVC can improve patients' vision and resolve CME in the treatment of I-CRVO-CME and NI-CRVO-CME, but the effect of treatment of NI-CRVO-CME is better than that of I-CRVO-CME.