The advancement of social economy promotes the establishment of anesthesia and surgery and the application of special surgical instruments, thus boosting the rapid development of the surgical treatment targeted at dento-maxillofacial deformities. Orthognathic surgery is the most effective treatment to improve malocclusion. Due to large trauma and abundant innervation of maxillofacial nerves, patients often experience severe pains after operation. Pains can lead to physiological and psychological changes in patients and affect early rehabilitation and functional exercise. Because of the swelling of the surgery site and the limitation of opening mouth after orthognathic surgery, opioid medicine is not suitable for such patients. Based on sufficient analgesia, it is necessary to avoid the onset of complications such as nausea, vomiting and respiratory depression as far as possible. Ultrasound-guided jaw nerve block technique can not only provide satisfactory analgesic effect, reduce intraoperative bleeding and promote early postoperative functional exercise, but also is accurate, user-friendly and quite secure. This paper mainly describes the clinical effect of jaw nerve block, the research and operational procedures of ultrasound-guided jaw nerve block, in order to provide reference for the application of this technology in orthognathic surgery.