Objective To review the clinical data of patients with hepatitis B cirrhosis complicated with portal hypertension undergoing transjugular intrahepatic portosystemic shunt (TIPS) with Fluency or Viatorr covered stents were reviewed, and to compare the clinical efficacy and the outcome in patients receiving the two different treatment modalities.Methods From June 2015 to January 2021, a total of 110 patients with hepatitis B cirrhosis complicated with portal hypertension undergoing TIPS with Fluency or Viatorr covered stents were collected, including 77 males and 33 females with the age ranged 37 to 74 years old. They were divided into Fluency group and Viatorr group according to stent types, and the general data, the incidence of stenosis and occlusion of the TIPS stents, the time to a second TIPS, and portal venous pressure before and after the treatment were compared between the two groups. The patients were further followed up to determine and compare the incidence of complications and the cause of mortality between the two groups.Results Regarding the clinical symptoms, 95 cases (86.4%) were present with upper gastrointestinal bleeding caused by portal hypertension, while there were 15 cases (13.6%) of refractory ascites. After the treatment, stenosis and occlusion of the TIPS stents occurred in 26 cases (23.6%) and 23 cases (20.9%) out of the 110 patients, respectively. There were 15 cases (19.5%) and 8 cases (10.4%) of hepatic vein thrombosis and portal vein thrombosis, and 6 cases (7.8%) and 5 cases (6.5%) of hepatic vein tortuosity and portal vein tortuosity occurring in the Fluency group, while there were 3 cases (9.1%) and 1 case (3.0%) of hepatic vein thrombosis and portal vein thrombosis, and 1 case (3.0%) of hepatic vein tortuosity occurring in the Fluency group. The rates of stenosis and occlusion of the TIPS stents in the Viatorr group were lower than those in the Fluency group (P<0.05). The time to a second TIPS in the Viatorr group was longer than that in the Fluency group (P < 0.05). The portal venous pressure before the treatment were higher than those after the treatment in both the Fluency group and the Viatorr group (P<0.05). After 6 to 17 months of follow-up, common complications including 17 cases of nausea and vomiting (15.5%), 10 cases of hemorrhage at the puncture site (9.1%), 4 cases of transient respiratory distress (3.6%), 3 cases of intraperitoneal hemorrhage (2.7%), and 1 case of hemobilia (1.0%) were observed in patients undergoing TIPS. A total of 15 mortalities occurred during the follow-up period, where the death causes included 9 cases of hepatic failure (8.2%), 4 cases of severe hepatic encephalopathy (3.6%), and 2 cases of recurrent variceal hemorrhage (1.8%). There was no difference in the complications and death causes between the two groups (P > 0.05).Conclusions The incidence of stenosis and occlusion of the TIPS stents is low when Viatorr covered stents were applied. However, there is no obvious difference in short-term efficacy and complications between patients undergoing TIPS with Fluency and Viator covered stents, which awaits further investigation.