Obesity is one of the important risk factors for coronary heart disease.At present, the number of obese people in the world is increasing year by year, especially in China.Dysregulation of adipokine production by adipose tissue can lead to the development of obesity-related metabolic diseases and coronary heart disease.Nesfatin-1 is a new type of adipokine. Current studies have shown that Nesfatin-1 has cardiovascular disease-related effects such as inhibiting food intake,regulating energy metabolism, regulating blood pressure and regulating atherosclerosis and regulating heart function.Nesfatin-1 and other adipokines have become research hotspots in recent years.Therefore, this paper summarizes the effects of Nesfatin-1 on cardiovascular function.Hope to provide some new ideas and new methods for the diagnosis and treatment of cardiovascular diseases, and even to provide help for the prognosis of cardiovascular diseases.